IL 28A is one of type III interferons, which are upregulated in response to viral infection as antiviral molecules, and they act predominantly on epithelial cells through a receptor complex that contains IL-10 R beta and IL-28 R alpha /IFN-gamma R1, and induce the upregulation of MHC class I antigen. IL-28A promotes the Th1 polarization of dendritic cells in the airway and inhibits Th2 and Th17 mediated inflammation. In addition, IL-28A has anti-tumor activity (1-5).
Reviews
There are no reviews yet.