Human TNFa
Human TNFa
APC1 protein; Cachectin; Cachetin; DIF; TNF; TNF, monocyte-derived; TNFA; TNF-A; TNFalpha; TNF-alpha; TNF-alphacachectin; TNFATNF, macrophage-derived; TNFG1F; TNFSF1A; TNFSF2; TNFSF2TNF superfamily, member 2; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; Tumor necrosis factor ligand superfamily member 2; tumor necrosis factor; tumor necrosis factor-alpha
$82.00 – $1,500.00
TNFa is a pleiotropic molecule that plays a central role in inflammation, immune system development, apoptosis, and lipid metabolism. Human TNFa is composed of a 35 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 177 aa extracellular domain (ECD). It is produced by a wide variety of immune, epithelial, endothelial, and tumor cells and is assembled intracellularly to form a noncovalently linked homotrimer on the cell surface. Cell surface TNFa can induce the lysis of neighboring tumor cells and virus infected cells (1-5).
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