Mouse FGF2

FGF2 is one of at least 22 mitogenic proteins of the FGF family, and it can be located in both the cytoplasm and the nucleus and is presumed to be the form secreted. Binding of FGF to heparin or cell surface HSPG is necessary for binding, dimerization and activation of tyrosine kinase FGF receptors. Expression of FGF2 is nearly ubiquitous but disruption of the mouse FGF basic gene gives a relatively mild phenotype. FGF2 modulates such normal processes as angiogenesis, wound healing and tissue repair, embryonic development and differentiation, neuronal function and neural degeneration (1-5).