Mouse IFNg, 1 mg

IFN-gamma (interferon-gamma) is a prototype proinflammatory cytokine, and mature mouse IFN-gamma exists as a noncovalently linked homodimer of 20-25 kDa variably glycosylated subunits. IFN-gamma dimers bind to IFN gamma RI (alpha subunits) then interacting with IFN-gamma RII (beta subunits) to form the functional receptor complex of two alpha and two beta subunits. IFN-gamma is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells, and it plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, up-regulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects (1-5).