Human IGF1

Insulin-like growth factor I (IGF-I or IGF-1), also known as somatomedin C is synthesized as two precursor isoforms with N- and alternate C terminal propeptides. IGF-I induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally. IGF-I regulates glucose and fatty acid metabolism, steroid hormone activity, and cartilage and bone metabolism. It plays an important role in muscle regeneration and tumor progression. IGF-I/IGF-1 binds IGF-I R, IGF-II R, and the insulin receptor, although its effects are mediated primarily by IGF-I R. The IGF-I protein associates with IGF binding proteins thereby increasing its plasma half life and modulating its interactions with receptors.