Interleukin 15 (IL-15) is a widely expressed 14 kDa cytokine that is structurally and functionally related to IL-2 and plays an important role in many immunological diseases. The IL-15 protein binds with high affinity to IL-15 R alpha and with lower affinity to a complex of IL-2 R beta. IL-15 exhibits anti-tumor activity independent of its actions on NK cells or CD8+ T cells. It also inhibits the deposition of lipid in adipocytes, and its circulating levels are decreased in obesity.
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