Human IL28B, 1 mg

IL-28B (also named interferon-lambda 3, IFN-lambda 3), IL-28A (IFN-lambda 2) and IL-29 (IFN-lambda 1) are type III interferons as class II cytokine receptor ligands. They signal through a widely expressed receptor that is a heterodimer of the IL-10 receptor beta and IL-28 receptor alpha, activating similar pathways, including JAK/STAT signaling pathway. Both type I and III IFNs induce anti viral activity and up regulate MHC class I antigen expression. In vivo Type III IFNs have shown anti-viral activity, anti-proliferative and antitumor activity (1-5).