Human IL3

IL3 (interleukin 3) is a pleiotropic factor produced by activated T cells primarily and other cell types including human thymic epithelial cells, activated murine mast cells, murine keratinocytes and neurons/astrocytes. IL3 can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells, various lineage committed progenitors, and affects the functional activity of mature mast cells, basophils, eosinophils and macrophages. Notably, IL-3 activity is highly species-specific, so human IL-3 does not show activity on murine cells. IL-3 acts through binding to specific cell surface receptors, which are present on bone marrow progenitors, macrophages, mast cells, eosinophils, megakaryocytes, basophils and various myeloid leukemic cells.