Human THY1

Thy1 is a glycoprotein that mediates cellular adhesion and exerts a wide range of effects in different tissues. It is expressed on hematopoietic progenitor cells, lymphoid cells, neurons, and activated vascular endothelial cells, and it can form dimers and higher order multimers. Thy1 binds to heparin, the proteoglycan Syndecan-4, and Integrins alpha M beta 2, alpha V beta 3, and alpha V beta 5, inhibiting neurite outgrowth, and promoting astrocyte adhesion, mediating the adhesion and extravasation of leukocytes and melanoma cells, supporting the Thrombospondin-1 induced disassembly of fibroblast focal adhesions, and inhibiting the activation of latent TGF-beta 1, myofibroblast differentiation, and lung fibrosis (1-5).