Mouse IL15

Interleukin 15 (IL-15) is a widely expressed 14 kDa cytokine that is structurally and functionally related to IL-2 and plays an important role in many immunological diseases. IL-15 binds with high affinity to IL 15 R alpha. IL-15 associates with IL-15 R alpha in the endoplasmic reticulum, and this complex is expressed on the cell surface. IL-15 induces or enhances the differentiation, maintenance, or activation of multiple T cell subsets including NK, NKT, Th17, Treg, and CD8+ memory cells. IL-15 exhibits anti-tumor activity independent of its actions on NK cells or CD8+ T cells. It also inhibits the deposition of lipid in adipocytes, and its circulating levels are decreased in obesity (1-5).