Human IL8

IL8 _interleukin-8 _ is a widely expressed proinflammatory member of the CXC family of chemokines. IL-8 can function as a homodimer or a heterodimer with PF4 and it can also interact with matrix and cell surface glycosaminoglycans. IL8 promotes neutrophil adhesion to the vascular endothelium and migration to sites of inflammation, and tt triggers the antimicrobial activation of neutrophils through CXCR1. IL8 also binds to Serpin A1/alpha-1 Antitrypsin, and this prevents IL-8/CXCL8 interaction with CXCR1. IL8 is upregulated in atherosclerotic lesions and other cardiac pathologies where it exacerbates inflammatory tissue damage, and it induces VEGF expression, vascular endothelial cell proliferation, angiogenesis, and tumor cell invasiveness (1-5).